|
KMID : 0624620080410090645
|
|
BMB Reports
2008 Volume.41 No. 9 p.645 ~ p.650
|
|
|
Arabidopsis nucleoside diphosphate kinase-2 as a plant GTPase activating protein
|
|
Shen Yu
Han Yun-Jeong
Kim Jeong-Il
Song Pill-Soon
|
|
|
Abstract
|
|
|
|
Nucleoside diphosphate kinase (NDPK) is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Arabidopsis NDPK2, like its mammalian counterparts, is multifunctional despite its initial discovery phytochrome-interacting protein. This similarity raises the possibility that NDPK2 may play a role in G-protein signaling in plants. In the present study, we explore the potential relationship between NDPK2 and the small G proteins, Pra2 and Pra3, as well as the heterotrimeric G protein, GPA1. We report a physical interaction between NDPK2 and these small G proteins, and demonstrate that NDPK2 can stimulate their GTPase activities. Our results suggest that NDPK2 acts as a GTPase-activating protein for small G proteins in plants. We propose that NDPK2 might be a missing link between the phytochromemediated light signaling and G protein-mediated signaling.
|
|
|
KEYWORD
|
|
|
Arabidopsis NDPK2, GTPase activating protein, Light signaling, Phytochrome, Plant NDPK, Small G protein
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|